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Best natural ADHD supplements & nootropics reviews & remedies for adults | Natural OTC Adderall, non-prescription ADD medication – legal stimulants, dopamine, herbs, L-tyrosine, vitamins & non-stimulant meds (Strattera, Qelbree) alternatives



Best overall, OTC holistic ADHD & inattentive ADD supplements/nootropics for adultsMind Lab Pro and Brain Pill

Best dopamine-based nootropic supplements for ADHDMind Lab Pro, Individual dopaminergic supplements from BulkSupplements e.g.- N-Acetyl L-Tyrosine, Mucuna Pruriens

Best ginkgo biloba ADHD supplementBrain Pill

Best natural legal stimulant & natural, herbal Adderall/Ritalin over the counter for ADHDMind Lab Pro

Best calming supplements for ADHD with hyperactivity & anxiety –  Bacopa Monnieri & Ginkgo Biloba ( from Brain Pill ),  Performance Lab Sleep, Relax CBD full spectrum gummies 3500mg and Diamond CBD broad spectrum + Melatonin calm bedtime gummies

Best CBD for ADHDYum Yum CBD isolate 1500mg and Yum Yum Gummies CBD Full Spectrum 3500mg

Best natural supplements for ADHD & DepressionMind Lab Pro and Accentrate 110

Best calm gummies for ADHD –  Performance Lab Sleep, Natural Vitality Calm (for kids) and Relax CBD full spectrum gummies 3500mg (for adults)

Best preworkout for ADHDPreLabPro

– Best focus multivitamins & omega 3 (EPA & DHA) for adults with ADHD –   Accentrate110 and Performance Lab® Omega-3

Best ADHD supplements at GNC for adults: Procera XTF Extreme Focus & Focus Fast

Best broad-spectrum micronutrients (vitamins & minerals) for ADHDPlab Multimen and Multiwomen, MZI from Accentrate and Hardy Nutritionals Daily Essential Nutrients 360


Legal OTC Medication for ADHD

Traditionally, stimulants (such as Adderall) are usually prescribed for ADHD, and for some people, it usually does the trick!

However, some people find that stimulants can be a little too much and for those, nootropics & focus pills offer a great stimulants-free alternative therapy.

Nootropics vs. Stimulants

Stimulants treat ADHD by directly working on the brain’s neurotransmitters. Most stimulants’ actions are linked to the levels of dopamine, norepinephrine, and epinephrine in the brain.

While nootropics do affect the same chemicals and neurotransmitters, they do so through a different pathway. For instance, some nootropic supplements for ADHD like Mind Lab Pro and Brain Pill contain dopamine-enhancing stimulants ingredients, but they’re not as intense as the traditional stimulants.

So, they are perfect alternatives to someone who is either looking for a “non-prescription” ADHD treatment/drug or alternative to non-stimulant ADHD medications like Strattera, Qelbree etc.

Below, we also discuss other over the counter legal stimulants similar to Adderall, Ritalin & other ADHD meds.

Managing ADHD symptoms with supplements, herbs & nootropics


Though there is a broad range of symptoms of ADHD, some of the most crucial ones include:

  • Trouble focusing or concentrating on tasks
  • Easily Sidetracked
  • Difficulty sitting still for long periods of time
  • Impulsive behaviors
  • Hyperactivity
  • Challenges in getting organized
  • Avoidance of tasks
  • Forgetfulness
  • Problems with interrupting

Many of the several kinds of supplements we list in this article are focused towards lessening the consequences of one or more of these symptoms. Some of the supplements are meant to be complementary treatments for ADHD, for example, usually taken with Adderall, though clinical studies are still being done on their standalone benefits.

A nutritional supplement may furnish best possible nutrients & herbal ingredients for optimal brain function that you may not be getting from your food. Moreover, some botanicals or herbal products are plant-based products that are not necessarily nourishing, but may help provide positive effects on mental health and function.

Best supplements/nootropics/individual ingredients for ADHD symptoms-wise


Attention and Processing: NALT (N-Acetyl-L-Tyrosine), Rhodiola Rosea, Tyrosine, Phosphatidylserine (PS), SAM-E, Omega 3

Focus: Choline, Methylliberine (Dynamine®), Ginkgo Biloba, SAM-E

Memory, Learning, reducing forgetfulness: Bacopa Monnieri (Synapsa®), Alpha GPC, Omega 3

Impulsive behaviors/Hyperactivity: Bacopa monnieri (Synapsa®), Rhodiola Rosea, L-theanine, Valerian root, Melatonin

Energy and Fatigue: Vitamin B12, Choline, SAM-E, NALT (N-Acetyl-L-Tyrosine)

Mental Sharpness: DHA, Mangifera Indica fruit extract

Mood and Stress: Tyrosine, Mucuna Pruriens, Saffron extract, Agmatine


What are the best nootropics, supplements, herbs & otc stimulants for ADHD?


1. Omega-3 Fatty Acids

Category: Fish Oil, Omegas, Fatty acids, Nootropic

For: Hyperactivity, impulsivity, attention

Omega-3 supplements have been around since forever, yet there’s so much debate about the optimal dose and how to give it for ADHD.

It’s well known that fish oil is particularly rich in omega-3. The key players of the omega-3 fatty acids are EPA and DHA, which offer most of the cognitive improvement effects. Two meta-analyses found that omega-3 can improve ADHD when it comes to hyperactivity, impulsivity, and attention. It’s considered one of the most-researched supplements for ADHD & ADD and all researches showed promising results.

Docosahexaenoic acid (DHA) is an essential neurological development nootropic for brain performance & health. Several studies indicate that a deficiency in DHA is specifically linked to cognitive decline in healthy grownups and individuals with Alzheimer’s. Users also document that it improves reaction time and mental sharpness.

Rule of thumb: There should be 1.5 to 2 times as much EPA as DHA. It is recommended a total of 1,000 mg of EPA plus DHA (add the two together) for smaller children, 2,000 mg for adolescents, and 1,500 mg for those in between.

What are the best Omega-3 supplements for ADHD? Performance Lab® Omega-3 , Accentrate and BioSchwartz Omega-3 Fish Oil

  • These are among the most potent omega 3 supplements out there for ADHD!
  • Packed with Fish Oil, Omega-3 Fatty Acids, Natural Lemon Oil
  • Suitable for individuals over 18
  • Pregnant and Breastfeeding mothers should consult physician before using
  • Non-GMO ingredients
  • Up to three soft gel capsules can be taken daily with meals.


2. Alpha GPC/Citicoline

Category: Nootropic

For: Mental edge, memory, focus, anxiety

The brain transmitter acetylcholine can’t exist without choline, and that’s why it’s not a surprise that Alpha GPC & other choline supplements like Citicoline have been proven to have an impressive effect on memory. 400mg of Alpha GPC, three times a day, can improve the mental impairments in patients with mild to moderate dementia. [Source]

This highly effective chemical has been available as a prescription drug as citicoline since 1970 but now, the new and improved version of it, Cognizin® Citicoline (enhanced & patented form of Citicoline) is available to whoever needs a brain pick-me-up throughout his day.

Alpha GPC & Cognizin don’t only give you a mental edge, they can also give you a little extra physical boost as well as it’s been found to improve output in athletes.  Choline from these choline supplements may also help with anxiety that comes with ADHD. For best choline/Cognizin supplements for ADHD, we recommend Mind Lab Pro and Brain Pill.

3. Ginkgo Biloba

Category: Herb, Nootropic

For: Restlessness, impulsivity, anxiety, irritability, focus

The leaves of the Ginkgo Biloba contain Terpene Trilactones, a substance that has been proven to have a protective function on the brain cells, as well as a dopamine-boosting effect. [Source]

A double-blind randomized trial showed that in the treatment group that had ginkgo added to their treatment, there was a 35% improvement in attention.

One of Gingko’s major effects comes from its ability to lessen the restlessness and impulsiveness of ADHD, some of the everyday warning signs of inattentive ADHD. When combined with ADHD drugs like Adderall, Ritalin, Vyvanse, etc. it has been helpful to ease irritability, anxiety, and frustration.

Where to find it?

Brain Pill (Our top recommendation for Ginkgo Biloba for ADHD & ADD)

BulkSupplements Gingko Biloba

Nutricost Ginkgo Biloba (120mg)

Review: This high-quality gluten-free supplement features top-notch quality Gingko Biloba Extract with 24% Ginkgo Flavone Glycosides. It also provides powerful antioxidant action and is non-GMO.

Healthy Care Ginkgo Biloba (2000mg)

Review: Gluten-free ginkgo biloba supplement for ADHD, this product offers a regulating effect on the body’s circulation resulting in a feeling of ease and relaxation. However, this product is not suitable for children under 12. It helps boost mental functions and cognitive performance.

4. Nalt (N-Acetyl-L-Tyrosine)

Category: Nootropic, Amino acid

For: Mental edge, memory, focus, anxiety, mood

NALT (N-Acetyl-L-Tyrosine) is a more bio-available version of L-Tyrosine/Tyrosine: an amino acid that’s used to produce noradrenaline and dopamine. It elevates working memory, executive function, creative flow states, stress reduction, better mood, anti-anxiety and reduces symptoms of ADHD. It can ease alertness, energy, and neurological function. Per, it also has potential to lower stress levels and prevent stress-induced memory and attention deficits. NALT operates in synergy with pharmaceutical drugs like Ritalin and Adderall by increasing extracellular levels of dopamine.

5. Magnesium

Category: Mineral

For: Irritability, confusion, anxiety, calmness, sleep

Magnesium is one of the most necessary minerals for brain health, we need it to transfer nerve signals, control blood sugar and blood pressure levels. It can also produce calming effect on brain.

Lack of Magnesium in our bodies has been directly linked to ADHD in a recent study and magnesium supplements have also aided ADHD patients with “rebound effect” after the effect of stimulants wears off. It was also shown that having low levels of magnesium can cause irritability, disorientation, confusion and a below-average attention span.

Using Magnesium along with Ginkgo Biloba (both taken together in the evening) has also been shown to intensify Vyvanse & to counter “tolerance” (diminishing effect of psychostimulants with time). Studies on Magnesium have also been done on hyperactivity and autism in children.

It should be noted that high doses of magnesium can cause nausea, diarrhea, or even toxicity. Before adding any magnesium to your or your child’s treatment plan, make sure to consult your physician and see if it’s a right fit.

Chelated form of Magnesium is best form & recommended because of its great bioavailability. Magnesium Threonate is also good for ADHD.

What’s best Magnesium supplement for ADHD? We recommend MZI from Accentrate (Magnesium Glycinate Chelate) and OMG! Nutrition Magnesium Drink Mix (200mg)

OMG Magnesium Drink is perfect for those with an irritable stomach that might feel nauseous after taking traditional magnesium supplements. It’s gut-friendly, soy-free, and dairy-free, making it as gentle as it could be to the stomach.

6. Tyrosine

Category: Nootropic, Amino acid

For: Mental edge, memory, focus, anxiety, mood

This all-natural substance is well-known for super swift memory recall, even under stressful conditions which makes it a vital one-of-a-kind nootropic component in various natural ADHD supplements.

Backed by several clinical studies, tyrosine or L-tyrosine has become extremely popular cognitive function enhancers & natural ADD supplements, for kids & adults equally and for some people, as a risk-free replacement of ADHD drugs like Strattera, Ritalin, Vyvanse etc.

7. L-theanine

Category: Nootropic, Amino acid, Herbal

For: Calming, attention, hyperactivity, mood

L-theanine is a calming amino acid that comes from tea leaves.  L-theanine boosts calmness, Upbeat, Focus, Relaxation, Attention and can tentatively improve your attention span and latency.

L-theanine is one of the best otc ADHD supplement for lessening hyperactivity. Suntheanine, a patented variety of l-theanine in Mind Lab Pro is one of best quality versions of theanine for ADHD.

8. Lion’s Mane

Category: Nootropic, Herbal

For: Mental edge, memory, focus, anxiety, clarity, mood

Lion’s mane benefits on ADHD (attention-deficit hyperactivity disorder) has seen much interest and some experts believe this natural supplement can be used as a natural therapeutic strategy in the treatment of ADHD. It’s proven to help with focus, memory, and clarity and also in relieving symptoms of anxiety and depression. Basically, lion’s mane aids in many of the symptoms of ADHD, even if the research is lacking on its effects on ADHD itself.

One study released in the Neuroscience Letters in 2014 confirmed that children with ADHD have unregulated NGF levels and they might have an important part in the pathophysiology of ADHD.  Considering NGF has a significant role in the neurons’ development & repair and is fundamental to neuroprotective activities, the neurotrophic actions of lion’s mane may benefit ADHD as a potential therapeutic & help enhance cognitive function while managing ADHD symptoms.

9. Pycnogenol

Category: Nootropic, Herbal

For: Hyperactivity, Attention, Focus, Stress, Memory

Also called the French Maritime Pine Bark, Pycnogenol extract might be a way to treat the hyperactivity that comes with ADHD. However, while it has proven to have some effect on reducing hyperactivity, and enhancing attention, concentration, and memory, it’s still undergoing research regarding its safety and efficacy.

Nevertheless, this extract shows promising effects as an antioxidant and may work in reducing oxidative stress, improving blood flow, and hence, brain functions as well.

Where to find it?

Mind Lab Pro

Nature’s Way Pycnogenol (50mg)

  • All-natural proanthocyanidins, organic acids, and other biologically active components.
  • Powerful antioxidants such as vitamin E
  • Gluten-free and vegetarian friendly

Bestvite Pycnogenol (100mg)

  • Research-backed Pycnogenol that has been used for over 40 years
  • No traces of Magnesium Stearate
  • Featuring the French Maritime Pines’ rich flavor
  • Gluten-free

10. Valerian Root

Category: Nootropic, Herb

For: Hyperactivity, Calming, Sleep

No brain can function perfectly without proper sleep, but ADHD can make sleep harder and less sleep can make ADHD symptoms worse.

Valerian has been long-known for its relaxing & sleep-inducing properties. In one study, it was found that simply ingesting Valerian in the hour before bedtime, can help improve hyperactivity symptoms in children.

Valerian also has the extra benefit of being completely safe to use, even with larger doses, making it a suitable option for both adults and children who are in need of a good night’s sleep.

Where to find best Valerian root supplements for ADHD?


11. Bacopa monnieri for ADHD

Category: Nootropic, Herb

For: Hyperactivity, memory, focus, anxiety, calming


Bacopa Monnieri, or Brahmi for short, has been widely used as an alternative treatment for many health problems, especially ones located in the brain including stress, Alzheimer’s disease, memory loss, anxiety, attention deficit-hyperactivity disorder (ADHD) symptoms, epilepsy etc.

Research has found that a substance called Bacosides in the Bacopa Monnieri can actually improve nerve impulses between the neurons in our nervous system, something that can hold promising results for ADHD patients.

A sense of ease and relaxation comes with using Bacopa, making it helpful for the hyperactive and impulsive component of ADHD & making it a good otc alternative to Guanfacine. Not to mention, its brain function boosting effect can help improve memory functions too, so it’s common ingredient in memory supplements.

Synapsa is a powerful patented Bacopa Monnieri extract found in natural ADHD products like Mind Lab Pro and Brain Pill. A daily dose of this powerful ingredient can ignite calmness, rapid recall, sharp memory, & help with forgetfulness.

12. Rhodiola Rosea

Category: Nootropic, Herb

For: Fatigue, Attention, Irritability

You’ve probably come across this famous adaptogen’s name before.

This famous nootropic was the star of many types of research, including a clinical trial where it helped reduce fatigue in physicians, taking the term “doctor-approved” to a whole new level! It was also “able to improve performance on work-related tasks by approximately 20%.”

Rhodiola Rosea is now gaining more and more attention. For starters, it can improve cognitive function due to its superb anti-fatigue effects. Not to mention, many types of research point to its positive effects on improving attention and alertness, offering promising benefits to ADHD patients.

13. SAM-e

Category: Nootropic

For: Focus, Energy, Fatigue, Irritability, Mood

S-adenosyl-L-methionine (commonly called “SAM-e”) is a natural compound contained in all cells of human body where it is essential in more than 200 metabolic pathways. Latest clinical research has demonstrated appealing prospects for treatment of depression, dementia, and experts have suggested that SAM-e may also help address ADHD. People using SAM-e for ADHD may experience improved concentration, energy, alertness, and feelings of well-being.

SAM-e helps produce and breakdown the neurotransmitters acetylcholine, dopamine, serotonin, norepinephrine and melatonin in your brain.  SAM-e is commercialized as brand names Adomet, Gumbaral, Samyr, Heptral, Agotan, Donamet, Isimet and Admethionine etc.

14. Phosphatidyslerine

Category: Nootropic

For: Memory, Focus, Cognitive function

Phosphatidylserine acts directly on a cellular level, enhancing the transmission of signals between different cell types, including neurons, which makes it beneficial for ADHD patients.

The effect it has on cell-signaling is crucial in its role in maintaining cognitive function & improving the brain’s health. Therefore, it comes as no surprise that it can improve concentration, memory, and language skills, even in older patients who suffer from cognitive deterioration.

Phosphatidylserine is derived from fatty acids and can be taken on its own or along with omega 3 supplements. Our top recommendations for ADHD, both have Mind Lab Pro and Brain Pill.

15. Iron

Category: Mineral

We all know that iron runs in our blood, quite literally. It’s responsible for delivering oxygen to different organs around our body, including the brain. However, iron has another additional role when it comes to the brain, which is the production of dopamine.

A study found that 84% of children with ADHD actually had lower iron levels than those without it. Also, those with lower levels of ferritin (the protein that carries iron inside cells that store it), had more severe ADHD symptoms.

However, iron should only be supplemented where it’s lacking, which is something you can find out through a ferritin test. It’s extremely important not to take any iron supplements without medical approval.

What are some good iron supplements for ADHD?

Plab Multimen and Multiwomen

Nature Made Iron (65mg)

Review: This pharmacist approved supplement is derived from natural sources and needs to be taken only once a day, best with meals.

LifeCentric Health Iron Gummies

Review: Vegan-friendly and gluten-free gummy, for when the iron supplements get a bit too much. These gummies offer a great alternative for those who want a great tasting iron supplement.

16. Vitamin D

Category: Vitamins

Pregnant mothers with vitamin D deficiencies are more likely to have children with ADHD.

Strangely enough, although there’s a relationship between vitamin D levels and ADHD, giving vitamin D supplements doesn’t actually help any of the ADHD symptoms.

Nevertheless, vitamin D deficiency carries a wide variety of symptoms that might make the ADHD worse. It’s always a good idea to check vitamin D levels and correct them with your physician.

17. Zinc

Category: Mineral

For: Hyperactivity, Inattention, Energy

Zinc might not receive the same hype that different elements like omega-3 and iron do, but there’s still some positive research that acknowledge its benefits for ADHD.

Zinc was shown to reduce the needed dose of psychostimulants by nearly 40%, in order for the patient to function at an optimal level. This makes it the perfect add-on to reach for with Adderall or other stimulants. This is believed to be due to zinc’s synthesizing effect on dopamine and augmenting effect of stimulants like methylphenidate.

Rule of thumb: a 20-25 mg dose of zinc is considered safe to give without a blood test.

Need good sources of zinc? Try:

Plab Multimen and Multiwomen

Nature’s Potent Zinc (50mg) : A highly potent safe option for boosting your immune functions as well as your mental ones. However, not recommended for pregnant or breastfeeding mothers.

Spring Valley Zinc (50mg): Carefully designed pill that’s smooth with a coated texture, making the pill easy to swallow.

 18. Racetams for ADHD

Category: Nootropic

For: Mental edge, Focus, Hyperactivity, Impulsivity, Anxiety, Mood

Racetams can be a useful aid to promote focus and concentration in addition to enhancing all around cognitive performance. Some racetams, including phenylpiracetam, may be used on an as-needed basis due to the fact their effects are so obvious & predictable. Other racetams, like piracetam, may produce a more sustained benefit when used consistently. There are several users sharing their experiences on Reddit etc. on using different kinds of racetams & their expected effects.

Some of the Racetam nootropics employed by people for ADHD are:- phenylpiracetam, aniracetam, fasoracetam, oxiracetam, pramiracetam, nefiracetam

Other nootropics besides Racetam, that might have some benefits for ADHD are :- sulbutiamine, Adrafinil, Noopept, Centrophenoxine, Sunifarm etc.

19. Melatonin

Category: Nootropic, Hormonal supplement

For: Calming, Sleep, Hyperactivity, Impulsivity

As we mentioned before, a good night’s sleep can work miracles to your brain function the next day and therefore, your ADHD while sleep disturbances can worsen ADHD symptoms.

Melatonin is the natural hormone that our brain produces at night as a part of its physiological internal clock and regulating its levels can actually improve the quality of sleep.

In a recent study, the effects of melatonin were examined in children with ADHD who had sleep issues as a result of taking stimulant medicine. The results revealed that 60.8 % of participants had a significant improvement in their sleep issues after taking melatonin.

Reaching for melatonin at night to improve ADHD symptoms is a relatively safe way to get a deep night’s sleep. Still, it should always be guided by a pediatrician or a primary care physician.

What’s a good melatonin supplement for ADHD?

20. Methylliberine (Dynamine®)

Category: Nootropic, Herbal

For: Attention, Energy, mood

Methylliberine is a metabolite of caffeine that is isolated from the Kucha tea leaf and acts at adenosine receptors. Methylliberine is a molecule that’s present in coffee, tea, yerba mate, and cocoa. Scientific experiments have shown that it can enhance alertness, mood, and energy. Chemically, its composition is literally very similar to caffeine – and so are the effects on brain.

21. Inositol

Category: Nootropic

For: Hyperactivity, Impulsivity, Anxiety, Mood

A lot of different foods in different categories have inositol. However, the dietary sources of inositol usually only has traces of it. Inositol enhances the activity of serotonin in the brain, and thus plays a crucial role in mood and emotional balance.

The dose needed to improve ADHD’s agitation and anxiety, is around 12-18 grams a day, taken in two or three doses for adults. Children are another case as their dose is calculated according to their weight.

One of the best ways to take is as ADHD multivitamin supplements-  – Plab Multimen and Multiwomen.


Honorable mentions

Other herbs typically used for ADHD symptoms are “Gotu Kola for ADHD”, Ginseng (this Chinese herb may alleviate hyperactivity and inattentiveness) and Ningdong for ADHD (this may help to reduce some ADHD symptoms; similar to ginseng). Besides, other supplements that may have some use in managing ADHD symptoms are L-lysine, Calcium, Creatine, Coq10, Dimethylglycine (DMG), GABA, Guarana, 5 htp, Acetyl l carnitine, Grape seed extract, Probiotics, Krill oil, Alpha lipoic acid, Flaxseed oil etc.


Best over-the-counter commercially available natural ADHD nootropics supplements stacks


1. Mind Lab Pro

Review: The Mind Lab Pro nootropic has been tested and is probably now one of the best non-stimulant treatments for ADHD.

This research-backed nootropic supplement and non-prescribed Adderall alternative doesn’t only regulate the brain’s dopamine but carries a more holistic approach, improving other brain functions such as memory and mood along with attention. Not to mention, this non-narcotic ADHD medicine is rich in all the vitamins that boost neurological functions, including vitamins B6, B9, and B12.


  • Citicoline
  • Phosphatidylserine (PS) as sharp-PS green
  • Lion’s Mane Mushroom as Full Spectrum Extract
  • Bacopa Monnieri 24% bacosides with 9 bioactives
  • Rhodiola Rosea (3% rosavins/1% Salidrosides)
  • N-Acetyl-L-Tyrosine
  • Maritime Pine Bark Extract (95% proanthocyanidins)
  • Suntheanine L-theanine
  • Vitamins B6, B9, B12 as Nutrigenesis B6, B9, B12


2. Brain Pill

Review: Brain Pill is the embodiment of an all-in-one nootropic supplement for ADHD & inattentive ADD. It doesn’t only act on Attention Deficit but also on improving the forgetfulness that very often comes along with it.

It offers a remarkable combination of strong nootropics and herbal remedies, including Cognizin citicoline, Tyrosine, Bacopa Monnieri Synapse, Huperzine A, DHA Complex and several vitamin B types, that have undergone extensive testing and performed admirably in clinical trials.

Brain Pill boosts cognition, memory, stress reduction, learning ability, and neurogenesis while protecting the brain from oxidative damage.

Its ingredients are:- Cognizin citicoline, Tyrosine, L theanine, PS (Phosphatidylserine), Bacopa Monnieri Synapsa, Huperzine A, Gingko Biloba, Vinpocetine, DHA Complex, Vitamins B5, B6, B9, B12.

3. Accentrate110

Review: Accentrate110® is a natural supplement to manage inattention, emotional dysregulation & supports attention, memory, and focus.

According to some Accentrate 110 user reviews, this supplement has potential to provide enough relief that made them go off a stimulant (which was giving them side effects). Based on ingredients, company reputation and consumer reviews, it does seem a solid choice for those considering natural ADHD treatment. Some ADHD patients take the supplement with stimulant medication like Adderall while others use it to replace stimulants.

Accentrate 110 Ingredients

The Accentrate formula includes the following omega-3 fatty acids and vitamins:

  • Tissue-Targeted® EPA & DHA – Omega-3 fatty acids that are essential in shielding brain tissue and brain cell communication. The EPA and DHA in Accentrate’s formula are in phospholipid type, optimized for neurological benefits.
  • L-Methylfolate – B vitamin employed to treat or prevent low levels of folate in the brain.
  • Vitamin B6/Vitamin B12 – Low levels of these vitamins have been connected to cognitive deficiencies.
  • Vitamin D3 – Vitamin D3 Deficiencies are associated with several psychiatric disorders, including ADHD.
  • Riboflavin – B2 deficiencies have been linked to fatigue and brain dysfunction.


4. Onnit Alpha Brain

Review: The Onnit Alpha Brain formulation is composed of all-natural ingredients – herbs, vitamins, and organic products including Alpha GPC, Huperzia Serrata, L-Theanine, and Bacopa Monnieri. The ingredients have been clinically studied to enhance attention, focus, cognition, memory, and reaction time.

However, the nootropics employed in the formula might not necessarily work synergistically for ADHD; so you ought to have separate occasions for taking a nootropic for focus and one for say, stress relief.

Alpha Brain uses a proprietary blend and they aren’t clear about how much of each active ingredient their product contains. So, you’re left in the dark and have no knowledge of which nootropics worked well or not and whether the ingredients they incorporated were in adequate quantities to essentially work for better brain performance.

5. Thesis

Review: Previously known as, the company behind Thesis nootropics for ADHD has been around for several years & one of the biggest nootropic companies with several positive user reviews. With over 500,000 customers over the years, they’ve built up a vast & astonishingly heavy data set of nootropics research. Their coaches have a solid background in the health industry and are neurologists, doctors, pre-med CPTs, etc.

When you register for Thesis, you have to go through a short questionnaire to help their team & coaches learn about you. Then it runs your answers through their algorithm to complement you up with the nootropic combinations that would probably be most useful for you and your condition- ADHD, lack of focus, low drive & motivation etc.  A typical Thesis package has four different blends for example, Clarity, Creativity, Logic, and Energy.

6. Focus factor

Review: Focus Factor provides supplements that focus on supercharging brain health, enhancing cognition, remembrance, attention, and focus. The company has solutions in its lineup for all age groups, including kids. The product is available in different strengths and can be bought as singles or bundles. Focus Factor Original is their best nootropic supplement that improves memory, concentration, and focus. However, their formulations have proprietary blends so exact ingredients are not known.


  • Dimethylethanolamine bitartrate (DMAE is one of the extensive ingredients used in a proprietary blend, known for its ability to boost attention and motion disorders like Alzheimer’s disease)
  • Bacopin
  • N-acetyl tyrosine
  • L-pyroglutamic acid
  • Phosphatidylserine
  • Fish oil
  • Choline
  • Huperzine
  • L-Glutamine

Their product Focus Factor for Kids promises that it “encourages calmness, & focused concentration in youngsters” while also claiming it will help with memory.

7. Amen’s BrainMD’s “Focus & Energy” and “Attention Support”

Review: Working with Brain imaging, Dr. Amen learned that some prescription medications may harm brain and thus searched for non-toxic remedies for his patients and engineered supplements for memory, mood, focus, and other attributes. BrainMD offers ultra-pure, professional medical grade, ethically sourced dietary supplements that can provide optimal ingredients in effective dosages to enhance brain performance without prescription medication.

Dr. Amen’s BrainMD’s “Attention Support” review


  • Vitamin B6
  • Magnesium
  • Zinc
  • Phosphatidyl Serine
  • Pycnogenol Maritime Pine Bark extract
  • Choline

I am also very sensitive to caffeine or other energy products. So i started to take this product one pill a day and I have noticed after a day or two that my mind almost doesn’t fatigue. The BrainMD doesn’t give me more physical energy or mental energy like drinking a couple cups of coffee but it makes a huge difference in my overall alertness during the day. So if your story is similar to mines I suggest trying this product because it’s amazing. – User review

Dr. Amen’s BrainMD’s “Attention Focus & Energy” review


  • Green Tea extract (standardized to 95% polyphenols and 45% EGCG)
  • Sensoril Ashwagandha Extract – Withania somnifera, [standardized to 10% withania glycosides]
  • Rhodiola (Rhodiola rosea) Root Extract [standardized to 3% rosavins, 1% solidrosides]
  • Asian ginseng (Panax ginseng) Root Extract
  • Choline (as bitartrate)

I take Dr. Amen’s supplements and have found them to be very beneficial. This supplement took effect in just a few days and made quite a difference. I have ADD and this helped plus gave me energy and clarity. It is supposed to be a Mental Endurance Booster, promotes Concentration & Attention supports healthy stress response and is Caffeine-Free, Gluten-Free. – User review

8. Avantera Elevate

Review: Avantera Elevate is designed to boost your day-to-day mental performance. Based on the ingredients it should help provide more energy, greater focus, enhanced memory, improved mood etc. It is also one of the few ADHD supplements containing probiotics for your gut health, creating a healthy microbiome, and combining it with nootropic ingredients. Overall, Avantera Elevate has a good profile when it comes to ingredients to help manage symptoms of ADHD. However, they are not present in sufficient quantities.


  • Avantera Mood & Gut Health Blend
  • Turmeric
  • Lion’s Mane
  • Bioperine
  • Bacopa Monnieri
  • Avantera Focus & Energy Blend
  • CDP Choline
  • L-Theanine
  • Caffeine/Green Tea Extract


9. Neuriva Brain Performance Plus

Review: Neuriva Brain Performance Plus is a popular nootropic for cognitive enhancement. Some people speculate if Neuriva supplements would be good for ADHD, and the answer is: maybe. Some data demonstrates that Phosphatidylserine supplementation may diminish the symptoms of ADHD, and Neuriva contains the substance, although not in optimal amounts. Another ingredient Coffee cherry comprises of compounds that help in releasing of Brain-Derived Neurotrophic Factor (BDNF), a health protein necessary for learning and conversing with others and it helps lower brain aging as well. Overall, a hit or miss product for ADHD.


  • Coffee cherry
  • Phosphatidylserine
  • Vitamin B6, B12
  • Folic acid


10. Quantumind

Review: Evolvere Quantumind functions by enhancing the blood and oxygen circulation to the brain. This translates to more desirable performance, memory retention, and amplified attention span. It may boost all around brain health in conjunction with cognitive functioning too. In addition to enhancing circulation, the product may also raise the total key neurotransmitters needed for focus, learning and memory. However, for most people looking at it as an ADHD supplement might experience severe side effects with 300mg of Caffeine and 75mg of Hordenine, it being far from a safe combo.

Quantumind Ingredients

  • N-Acetyl-L-Carnitine
  • Tyrosine
  • Phenylethylamine
  • Caffeine
  • Alpha Lipoic Acid
  • Alpha-GPC
  • Ashwagandha
  • Phosphatidylserine
  • L-Theanine
  • Shilajit
  • Green tea Leaf Extract
  • Panax Ginseng
  • Hordenine
  • Black Pepper Extract


Frequently Asked Questions (FAQs)


How do we know that supplements improve ADHD symptoms?

Examining teacher and parent-completed ADHD surveys and checklists allows researchers to evaluate the true impact of these supplements. The majority of the time, the research demonstrates reductions in impulsivity, hyperactivity, or all three. However, it’s still worthy of mentioning that the impact of a single supplement on a child or adult is difficult to anticipate.

Are supplements as effective as ADHD medication?

Generally speaking, no. While useful, ADHD supplements do not have the same power over ADHD symptoms that medication has. However, these supplements have far fewer adverse effects than medications, and they are less likely to have serious side effects. It’s best to use these supplements as a component of an integrative therapy strategy that also includes treatments for education, parenting, sleep, and exercise.

Do supplements have side effects?

Although some supplements have adverse effects, they are often less severe and less frequent than those associated with ADHD stimulants. For instance, iron may result in stomach discomfort or constipation. Any symptoms that appear after beginning one or more supplements should be noted, and your doctor should be consulted.

How long will it take to see results after starting a supplement?

It’s different from one person to another.  Some families state that they started taking fish oil and noticed improvements within days; other families claim to have seen no improvement after a month. Generally speaking, it’s best to not rush into judging supplements until after a few months have passed.

What is best otc natural alternative to Adderall XR?

NALT(N-Acetyl-L-Tyrosine), is a more soluble, potent & longer lasting version of L-Tyrosine, an amino acid that’s used to produce noradrenaline and dopamine. Just like L-Tyrosine is considered natural Adderall alternative, NALT(N-Acetyl-L-Tyrosine) would be perfect yet cheaper extended-release version of natural Adderall. When combined with other otc cholinergic & dopamine boosters like Alpha GPC, citicoline, Ginkgo biloba, pine bark extract, as well as omega-3 fatty acids (all effective mood enhancers), this would be perfect nootropic stack to act as natural alternative to Adderall XR.

Do dopamine supplements work for ADHD? What are best supplements/nootropics that increase dopamine?

Many successful medications used to handle the symptoms of ADHD operate by increasing the impact of dopamine in the body. L-tyrosine, Citicoline, Alpha-GPC, Rhodiola Rosea etc. are some of the well-known natural non-prescription dopamine boosters & natural medication with potential to work for ADHD & depression.

Are nootropics & herbal supplements good at treating mild ADHD & inattentive ADD? What are their advantages over traditional medications?

Natural ADHD/ADD remedies for hyperactivity usually have no side effects.  Also, it’s important to note that besides the short-term side effects of ADHD drugs listed by the pharmaceutical companies, the long-term side effects of some drugs is not yet known.

Does combining Melatonin and Ritalin work well for ADHD?

Short-term usage of melatonin supplements is apparently risk-free for most people and effective in inducing sleep. As reported by one study, children with ADHD were able to sleep longer and fall asleep faster after taking melatonin on a daily basis combined with their ADHD medication over several weeks. Some people also experiment with natural calming supplements along with Ritalin, especially for inducing sleep, such as Performance Lab Sleep and “Diamond CBD Melatonin bedtime gummies“.

What are the best natural alternatives to non-stimulant ADHD meds like Strattera (atmoxetine) and Qelbree (Viloxazine)?

Currently, Mind Lab Pro, Brain Pill & Accentrate 110 seem to be safest, yet most effective natural, non-habit forming alternatives to non-stimulant ADHD meds like Strattera (atmoxetine) and Qelbree (Viloxazine). These supplements don’t come with side effects like increased heart rate, that come with Adderall & in some cases, come with Strattera.

What is the best racetam for ADHD ?

Since different racetams work a little different to each other, and every person’s brain chemistry is different, they also seem to affect people very differently. Aniracetam, Piracetam, Phenylpiracetam, Pramaracetam are usually the most tried & tested Racetams for ADHD. Some people actually noticed Fasoracetam to be the best out of the racetams for this purpose. It does a great task of minimizing task anxiety/general anxiety and simultaneously provide a nice calm ability to focus on it. Besides, although Noopept is not viewed as a racetam it also helps with focus on boring or undesirable tasks as well. Read more on Racetams for ADHD.

For someone having ADHD and looking to try racetams, one strategy is to consider a racetam sample pack (eg from Nootropics Depot) to try them all and see what works.

What are best legal over the counter stimulants similar to Adderall?

Currently Mind Lab Pro & Brain Pill are the best legal over the counter stimulants similar to Adderall.

What is the best nootropic stack for ADHD?

Any nootropic stack comprising of some stimulants and supplements like Ginkgo Biloba, L-Tyrosine, Ginseng, Bacopa Monnieri and vitamins & omega 3 fatty acids, would be a good nootropic stack for ADHD. We recommend Mind Lab Pro. It provides some the best nootropics for ADHD in one formula. It is also a thoroughly clean, premium-quality and stimulant-free nutritional supplement that optimizes brain functioning for long-range health and wellbeing even though encouraging all around cognitive improvement. Other recommended nootropic stacks for ADHD are –

STACK 1: L-tyrosine, Coffee + L-theanine, Phenylpiracetam, SAM-e

STACK 2: Alpha GPC/Citicoline, Omega 3, Phosphatidylserine, Rhodiola rosea

Is there a vitamin/multivitamin that gives energy & focus like Adderall?

Accentrate110® is a natural multivitamin supplement that manages inattention, emotional dysregulation & supports attention, memory, and focus and has helped some people get off the stimulants. Accentrate110® contains Tissue-Targeted® EPA & DHA, L-Methylfolate, Vitamin B6/Vitamin B12, B3, D3. They also offer MZI, offering magnesium in chelated form and supports attention, focus, mood, and overall well-being. However, it’s not perfect alternative to Adderall. We recommend combining it with Mind Lab Pro.

Is Atomoxetine like Adderall ?

Adderall is a stimulant medication that functions by blocking the reuptake of dopamine and norepinephrine to increase the levels of these neurotransmitters in the brain. Strattera also impacts the reuptake of norepinephrine, but it is non-amphetamine ADHD medication & not a stimulant (like Adderall) & considered one of the best non habit forming, non stimulant ADHD/ADD medications for adults. However, Strattera does have some of the same potential side effects as Adderall and other stimulants, like a faster heartbeat or increased blood pressure. Unlike Adderall, Strattera is non-addictive and non-controlled ADHD medication.

What are some best alternative holistic ADHD treatments?

For an all-natural alternative holistic ADHD treatment, combining over the counter “natural ADHD supplements” like Mind Lab Pro, Brain Pill & Accentrate 110 along with “Yoga”, Exercise, “Spending time outside”, and “behavioral therapy” are the best options. This is also one of the best ways to treat ADHD naturally without medication.

Some scientific tests suggest that yoga may effectively complement treatment for those suffering from ADHD. Research released in 2013 claimed vital benefits to conditions such as hyperactivity, anxiety, and social problems in boys with ADHD who did yoga consistently in addition to taking their daily medication.

In general, any kind of exercise helps brain function more effectively and efficiently. Exercise causes a boost in endorphins, which can enhance mood. Exercise also improves the brain’s levels of dopamine, norepinephrine, and serotonin, which heightens focus and attention.

Besides, spending time outside, and regular exposure to outdoors and green space is a safe and natural treatment that can be used to help people with ADHD.

Behavioral modification/therapy is an approach that works on fixing certain problematic behaviors and may help prevent them. This can also involve setting up goals and rules and training the brain & behavior properly for the child as well as for adults.

What’s the best natural ADHD medication for adults with anxiety and depression?

People looking for alternatives to SSRIs like Prozac, Zoloft (sertraline) or medications like Busiprone (BuSpar) for ADHD with anxiety & depression may benefit by combining nootropics or supplements that boost dopamine and boost serotonin levels. Combining a supplement like Mind Lab Pro (in the morning) with MZI or Diamond CBD Melatonin gummies (in the evening) can be a herbal/non-pharmacological approach to replace SSRIs for ADHD.

Does Strattera give you energy like Adderall & speed up metabolism?

Most Strattera users report higher energy, hyper focus and other similar effects, albeit not as strong as that come from Adderall. Higher levels of norepinephrine in the brain (caused by Strattera) help to make people more alert and ready for action with feelings of increased wellbeing and more energy.

Are there natural alternatives to Effexor (Venlafaxine), Wellbutrin (Buproprion) XL, dopamine based anti-depressants to treat ADHD?

Some natural nootropics & stimulants that enhance dopamine levels in the brain can in-effect act as alternatives to anti-depressants to treat ADHD. For example, Wellbutrin (Buproprion) is an off-label ADHD medication because of its dopamine bosting properties. We recommend these natural, safe stimulants for ADHD – Mind Lab Pro and Brain Pill. Other recommended natural dopamine boosters & stimulants that may help ADHD caused by low dopamine are L-tyrosine, NALT, Ginkgo Biloba, Alpha GPC/Citicoline, Iron, Zinc etc.

What’s a good alternative to Daytrana patch for adult ADHD & narcolepsy?

The Daytrana methylphenidate patch should be worn for a maximum of 9 hours a day and is considered for adult ADHD & narcolepsy. Some of its alternatives are Mind Lab Pro nootropic supplement, Methylin Oral Solution (short-acting liquid form of methylphenidate), QuilliChew ER: An extended-release form of methylphenidate, ProCentra: A short-acting liquid form of Dexedrine (dextroamphetamine). Mind Lab Pro is over the counter, natural alternative, while the other 3 are prescription meds.

Where can I get Strattera/Qelbree for sale without prescription?

If you don’t have a prescription for non-narcotic ADHD meds Strattera or Qelbree (viloxazine), you can get yourself diagnosed with ADHD online and receive prescription/otc meds through certain Telemedicine services like PlushCare, Minded, PushHealth, Klarity ADHD etc. Another option is to try over the counter Strattera (atmoxetine) & Qelbree (viloxazine) alternatives like Mind Lab Pro & Brain Pill.

What vitamins are best for ADHD?

Supplementing vitamins B and C may help relieve ADD and ADHD symptoms. Furthermore, vitamin B deficiency is associated with irritability and fatigue in children. Besides, Vitamin D deficiency carries a wide variety of symptoms that might make the ADHD worse. Several otc supplements for ADHD include Vitamins B5, B6, B9, B12, Vitamin C, Vitamin D3 etc. We recommend Plab Multimen and Multiwomen, Accentrate110 multivitamin for ADHD. Another noteworthy supplement is Hardy Nutritionals Daily Essential Nutrients 360.

What amino acids are best for ADHD?

NALT, L tyrosine, L lysine, L theanine, Creatine are some of the amino acids that may help manage some ADHD symptoms.

Is there any Adderall over the counter (legal otc amphetamines salts) that is stronger?

Mind Lab Pro is an effective substitute for Adderall and legal, herbal otc alternative to amphetamines salt that doesn’t need a prescription. This nootropic closest to adderall incorporates cognitive health improving ingredients like N-Acetyl-L-Tyrosine, Cognizin (Patented Citicoline), Lion’s mane, Bacopa Monnieri, L-theanine etc. that may help with enhanced focus & concentration, higher mental energy, boost in cognitive performance and memory retention. Some nootropic users also recommend products similar to Adderall such as Adrafinil (from Nootropics depot) or over the counter Modafinil (wherever it’s available) as stronger alternatives to Adderall.

How to increase dopamine naturally for ADHD with dopamine pills?

In addition to eating a balanced diet for dopamine, many potential dietary supplements & over the counter energy pills may help increase dopamine levels like Adderall, including probiotics, Mucuna pruriens, fish oil, N-Acetyl-L-Tyrosine, Ginkgo biloba and Ginseng etc. Vitamin D, Zinc, Iron, and Magnesium are also recommended for ADHD for their role in natural dopamine production. This, consequently, could help improve ADHD symptoms, inattentive ADD and boost brain function and mental health. The best strategy to use dopamine boosting pills for ADHD would be to try a natural nootropic stack with diverse dopamine enhancing ingredients like Mind Lab Pro and combine it with a multivitamin/fatty acid supplement for ADHD ie. Accentrate 110.

Are there herbal home remedies for adhd/ natural remedies for focus ?

Herbs like Ginkgo biloba, Rhodiola Rosea, Ginseng, Mucuna pruriens, and Passionflower may help calm hyperactivity. Essential oils of vetiver and cedarwood work well for strengthening focus and relaxing down, while rosemary and peppermint oils have been proven to boost alertness while enhancing memory. For adults struggling with a sleep disorder along with ADHD, melatonin foods and supplements, light therapy and neurofeedback therapy might assist in managing ADHD symptoms.

Does inositol with choline work for ADHD?

Some people experiment trying inositol with choline to treat their ADHD, depression or focus & attention issues. Some have found success with it. For others, they liked the way it made them feel at first (relaxed and it seemed to stop ruminating thoughts), but then had worst emotional episodes. For others, it has completely eliminated their amphetamine medication side effects. For others, it had noticeable effects in the first 6 months in terms of moderating the mood and generally helping to mellow out with Inositol working modestly for people with bipolar disorder and issues like mild depression. Overall, response to ADHD or other issues like depression is quite variable with Inositol and Choline supplementation. DHA plus Choline & Inositol is also a popular supplement for kids.

What’s the best GABA supplement for ADHD?

GABA supplements like BulkSupplements Pure GABA powder may help in reducing ADHD symptoms such as lower anxiety, an increase in mood stability, reduced seizure activity, better sleep, and a decline in comorbid ADHD symptoms.

What is the best alternative to Guanfacine?

According to some user reviews, Bacopa monnieri (Synapsa®) seems to be one of the best natural alternatives to Guanfacine in reducing symptoms of hyperactivity for ADHD, inducing calmness & inattentive ADD.


Natural ADHD pills and supplements are growing more popular everyday as people continue to search for pills or something that have the same effect as Adderall or ADHD meds, even legal amphetamine salts over the counter or to replace the traditional ADHD drugs (such as Ritalin, Dexedrine, Cylert, Strattera, Vayarin and, or antidepressants such as Desipramine, Wellbutrin).

However, they do not have the same fast and potent effect on ADHD symptoms as psychostimulant medicine does. ADHD-friendly supplements and non-pharmacological treatments for inattentive ADHD are good for concentration & calming when overcoming ADHD. The effectiveness of these treatments is difficult to measure, but they have significantly fewer adverse effects than prescription drugs and less risk of serious negative effects.

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